Domain Description
Objective
To examine the effect of early corticosteroids in non-COVID AHRF and to examine the effect of extended corticosteroids at 10 days in both COVID and non-COVID persisting AHRF.
Population
For the early domain: Adult patients admitted to the ICU for less than 72 hours receiving high flow nasal cannula, non-invasive ventilation, invasive ventilation, or extracorporeal life support for at least 4 consecutive hours for non-COVID acute hypoxemic respiratory failure with new unilateral or bilateral airspace disease on chest radiograph. For the extended domain: Adult ICU patients who have already received 10 days of corticosteroids for AHRF (either COVID-19 or other causes) with ongoing AHRF requiring HFNC, NIV, invasive ventilation, or extracorporeal life support.